A group of compounds belonging to the subclass of triterpenes within terpenes - a class of hydrocarbons. The general formula of triterpenes is C30H48, (C10H16)3. Fasciculols are polycyclic triterpenes with a lanostane skeleton, toxic to humans and other warm-blooded animals to varying degrees. They have been isolated from species of the genera Hypholoma and Hebeloma.
In mycological terms, two species of false honey mushrooms are most significant as carriers of fasciculols: the brick-red Hypholoma lateritium and the sulfur-yellow Hypholoma fasciculare (from whose species epithet the entire group of these compounds received its name). In hypholomas, fasciculols designated by letters from A to M, fasciculolic acids A-C, and fascicularones A and B have been found.
The brick-red false honey mushroom, previously often considered simply inedible due to its bitter taste, contains fasciculols B and C, which showed toxicity in experiments on laboratory animals, but are thermolabile - destroyed by heating. Therefore, boiling eliminates the toxicity of this species of false honey mushroom (and also removes the bitterness, clearly noticeable in the raw flesh of the mushroom), making it edible and suitable for frying and preserving. In many modern sources, this false honey mushroom is no longer classified as a poisonous or inedible species, having rightfully moved into the conditionally edible category.
Much more dangerous is the sulfur-yellow false honey mushroom, containing the most poisonous of the fasciculols - E and F. They are thermostable and resistant to high temperatures. Usually, a person cannot consume a large amount of this mushroom, as its bitterness does not disappear after heat treatment; in this case, poisoning is limited to gastrointestinal disorders, muscle weakness, and sometimes visual impairment, and after a few days the symptoms disappear on their own, without treatment. Specific antidotes to fasciculols E and F are not known to medicine, so only supportive treatment and sorbents are used. However, when large doses of these poisons enter the body, dystrophic changes in the liver and kidneys, muscle paresis, severe visual impairment, coma, and death from paralysis of the respiratory muscles are observed. In practice, fortunately, fatal poisonings with sulfur-yellow honey mushroom are unknown. A nasty mushroom, but an honest one, warning the eater of its toxicity with a bitter taste and repulsive odor - reminiscent of raw dug-up earth, not unpleasant, but completely unappetizing.
Other fasciculols are low-toxic and have no toxicological significance, as the hypholoma species containing them are rare and are not consumed even by mistake. There is no information about the content of fasciculols in the edible false honey mushroom Hypholoma capnoides, also known as the poplar honey mushroom; possibly, they are absent or thermolabile.
According to some data, the potential anti-inflammatory properties of fasciculols are currently being studied, but which specific ones are not specified in the source of this data (L. Protasyuk for thePharmaMedia). It is also mentioned there that fasciculols demonstrate an anticoagulant effect.
Fasciculols have not been found in representatives of other genera.